Randomness in topological models

p. 914-925There are two aspects of randomness in topological models. In the first one, topological idealization of random patterns found in the Nature can be regarded as planar representations of three-dimensional lattices and thus reconstructed in the space. Another aspect of randomness is related to graphs in which some properties are determined in a random way. For example, combinatorial properties of graphs: number of vertices, number of edges, and connections between them can be regarded as events in the defined probability space. Random-graph theory deals with a question: at what connection probability a particular property reveals. Combination of probabilistic description of planar graphs and their spatial reconstruction creates new opportunities in structural form-finding, especially in the inceptive, the most creative, stage.Tarczewski, R.; Bober, W. (2010). Randomness in topological models. Editorial Universitat Politècnica de València. http://hdl.handle.net/10251/695

Improvement of the system of modular inflated shells by means of physical modelling

The paper presents results of experimental research of modular inflated shells. Experiments carried out in the first phase showed that proposed connection between cushion modules has led to the creation of articulated joints and resulted in local instability. Thus, a new type of connection has been developed and new series of experiments have been carried out

Eksperymentalna powłoka żelbetowa

W twórczości projektowo-badawczej Wacława Zalewskiego znajduje się zrealizowana w 1965 konstrukcja eksperymentalna sprężonej powłoki betonowej wiszącej na heksagonalnym układzie łuków stalowych. Ze względu na ówczesny brak odpowiednich narzędzi badawczych oraz projektowych, ta skomplikowana statycznie i technologicznie budowla powstała w sposób doświadczalny na podstawie założeń koncepcyjnych Zalewskiego, który jednocześnie sprawował nadzór nad jej realizacją. Dynamiczne działania techniczne podczas realizacji konstrukcji mogą być klasyfikowane jako wczesne przejawy rozwiniętego w ostatnich latach poszukiwania formy obiektu architektonicznego określanego mianem ”form finding”. Przeanalizowanie założeń technicznych oraz technologii wznoszenia tego interesującego obiektu stanowią cel niniejszego artykułu. Ze względu na brak dostępnej dokumentacji autor opierał się na informacjach zebranych podczas rozmów z Wacławem Zalewskim i uzyskanych od niego fotografiach z realizacji obiektu

Structural saping of some early concrete structures in Wroclaw

p. 710-722The paper presents two examples of creative application of structural concrete from the beginnings of 20th century. Fascinating time of industrial development, emergence of new trends in the art and social changes opened new opportunities for architectural design. While some former tendencies remained still influential, new forms appeared, determined mostly by their structural system.Tarczewski, R.; Bober, W. (2009). Structural saping of some early concrete structures in Wroclaw. Editorial Universitat Politècnica de València. http://hdl.handle.net/10251/673

Improvement of the system of modular inflated shells by means of physical modelling

The paper presents results of experimental research of modular inflated shells. Experiments carried out in the first phase showed that proposed connection between cushion modules has led to the creation of articulated joints and resulted in local instability. Thus, a new type of connection has been developed and new series of experiments have been carried out

Structural Morphology

IASS-IACM 2008 Session: Structural Morphology -- "Shape and size optimization of shell structures with variable thickness" by Saartje ARNOUT , David DOOMS, Guido DE ROECK (K. U. Leuven) -- "Topological representation of natural and man-made structural forms" by Waldemar BOBER, Romuald TARCZEWSKI (Wroclaw University of Technology) -- "The polyhedric configurations in spatial structures" by Dimitra TZOURMAKLIOTOU (Democritus University of Thrace) -- "Analytical and computational form-finding" by David M. COOPER (independent

Hepatic complications of peptide receptor radionuclide therapy with Lutetium-177 and Yttrium-90 in patients with neuroendocrine neoplasm

Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors originating from neuroendocrine cells spread throughout the body, forming the so-called diffuse endocrine system. The gold standard in treating unresectable or disseminated, progressive, and well-differentiated NENs is therapy with radiolabeled somatostatin analogs (peptide receptor radionuclide therapy — PRRT). PRRT is a method based on peptides combined with beta-emitting radionuclides. The study aimed to assess the early and long-term liver complications after administration of Lutetium-177 or Lutetium-177 combined with Yttrium-90. We enrolled 27 patients treated with [177Lu]Lu-DOTATATE with an activity of 7.4 GBq (200 mCi) and 9 patients received the tandem treatment [90Y]Y-DOTATATE + [177Lu]Lu-DOTATATE with an activity of 3.7 GBq (50 mCi + 50 mCi). In the assessment of early as well as long-term complications, no significant effect of the applied treatment on the parameters of liver injury was found. Regarding liver function PRRT was a safe treatment for patients with highly or moderately differentiated, unresectable, or diffuse NENs

Renal Disturbances during and after Radioligand Therapy of Neuroendocrine Tumors—Extended Analysis of Potential Acute and Chronic Complications

Neuroendocrine tumors (NEN) are a group of neoplasms that arise from hormonal and neural cells. Despite a common origin, their clinical symptoms and outcomes are varied. They are most commonly localized in the gastrointestinal tract. Targeted radioligand therapy (RLT) is a treatment option which has proven to be successful in recent studies. However, the possible outcomes and true safety profile of the treatment need to be fully determined, especially by new, more sensitive methods. Our study aimed to present an extended analysis of acute and chronic renal complications during and after radioligand therapy using, for the first time in the literature, innovative and complex renal parameters. Forty patients with neuroendocrine tumors underwent four courses of radioligand therapy with [177Lu]Lu-DOTATATE or [177Lu]Lu/[90Y]Y-DOTATATE. Radioisotopes were administrated in intervals of 8–12 weeks, with concurrent intravenous nephroprotection. New detailed and sensitive renal parameters were used to determine the renal safety profile during and after radioisotope therapy for standard treatment of NEN. During the first and fourth courses of RLT, no change in the glomerular filtration rate (GFR) was observed. However, long-term observations one year after the treatment showed a 10% reduction in the GFR. During the first course of treatment, the fractional urea and calcium excretions increased, while the fractional potassium concentration decreased. The fractional calcium excretion remained highly increased in long-term observations. Decreases in urine IL-18, KIM-1 and albumin concentrations were observed during RLT. The concentrations of IL-18 and KIM-1 remained low even a year after therapy. The ultrasound parameters of renal perfusion changed during treatment, before partially returning to the baseline one year after therapy, and were correlated with the biochemical parameters of renal function. A permanent increase in diastolic blood pressure was correlated with the decrease in the GFR observed during the study. In this innovative and complex renal assessment during and after RLT, we found a permanent 10% per year decrease in the GFR and noticeable disturbances in renal tubule function. The diastolic blood pressure also increased

Long-Term Complications of Radioligand Therapy with Lutetium-177 and Yttrium-90 in Patients with Neuroendocrine Neoplasms

Background: Neuroendocrine neoplasms are a group of tumors deriving from neural crest. They can be located in every tissue, but most commonly in gastrointestinal tract. Targeted therapy with use of radionuclides is an available and acceptable way of treatment, but its long-term safety is still to be determined, especially with sensitive methods. Methods: Study was performed on a group of 42 patients. They underwent full cycle (4 courses; 8–12 weekly intervals) of radioligand therapy with [177Lu]Lu-DOTATATE alone or tandem therapy with [177Lu]Lu-DOTATATE+[90Y]Y-DOTATATE. Late and long-term marrow and renal complications were assessed. Analysis focused on comparing data before first, fourth, and one year after the last course of RLT. Results: Study showed decreasing of all blood parameters in long-term observation, especially in lymphocytes line. Type of radioisotope, other diseases, primary tumor location, BMI, gender or age did not affect results. The only factor that had influence on hemoglobin and erythrocytes was decreased renal filtration. In long-term observation almost 10% decrease of renal filtration was observed. Type of isotope, gender, age, BMI did not affect these results. Moreover, reduction of urine IL-18, KIM-1, and albumin concentration has been observed. Conclusions: Though low-grade complications of radioligand therapy are possible, it stay a safe method of NEN treatment where benefits outweigh the risk